Peculiarities of obtaining attenuated thermosensitive recombinants of influenza A virus at the end of the H3N2 epidemic cycle.
Identifieur interne : 002774 ( Main/Exploration ); précédent : 002773; suivant : 002775Peculiarities of obtaining attenuated thermosensitive recombinants of influenza A virus at the end of the H3N2 epidemic cycle.
Auteurs : F I Polezhaev ; L M Garmashova ; V I Rumovsky ; G I Aleksandrova ; A A SmorodintsevSource :
- Acta virologica [ 0001-723X ] ; 1980.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Anticorps antiviraux.
- génétique : Virus de la grippe A.
- immunologie : Vaccins antigrippaux, Virus de la grippe A.
- pathogénicité : Virus de la grippe A.
- Humains, Recombinaison génétique, Sous-type H3N2 du virus de la grippe A, Température.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Antibodies, Viral.
- genetics : Influenza A virus.
- immunology : Influenza A virus, Influenza Vaccines.
- pathogenicity : Influenza A virus.
- Humans, Influenza A Virus, H3N2 Subtype, Recombination, Genetic, Temperature.
Abstract
The conditions of obtaining thermosensitive recombinants of the virulent A/Leningrad/82/76 (H3N2) virus with two donors of attenuation, A/Leningrad/134/17/57 (H2N2) and A/Leningrad/9/37/46 (H0N1), were evaluated. The recombinants were obtained by various methodical approaches (hybridization of native viruses, cross-reaction and selection of recombinants at temperatures of 25, 32 and 40 degrees C) to study their effects on the degree of attenuation and the regularity of transmission of the ts marker. The recombinants examined varied in thermosensitivity which depended on the conditions of recombination of parent viruses. All recombinants studied, irrespective of their RCT40 marker, were innocuous for men.
PubMed: 6106378
Affiliations:
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Le document en format XML
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Smorodintsev</name></author></analytic><series><title level="j">Acta virologica</title><idno type="ISSN">0001-723X</idno><imprint><date when="1980" type="published">1980</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Viral (biosynthesis)</term><term>Humans</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza A virus (genetics)</term><term>Influenza A virus (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza Vaccines (immunology)</term><term>Recombination, Genetic</term><term>Temperature</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Anticorps antiviraux (biosynthèse)</term><term>Humains</term><term>Recombinaison génétique</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Température</term><term>Vaccins antigrippaux (immunologie)</term><term>Virus de la grippe A (génétique)</term><term>Virus de la grippe A (immunologie)</term><term>Virus de la grippe A (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antigrippaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Influenza A Virus, H3N2 Subtype</term><term>Recombination, Genetic</term><term>Temperature</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Recombinaison génétique</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Température</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The conditions of obtaining thermosensitive recombinants of the virulent A/Leningrad/82/76 (H3N2) virus with two donors of attenuation, A/Leningrad/134/17/57 (H2N2) and A/Leningrad/9/37/46 (H0N1), were evaluated. The recombinants were obtained by various methodical approaches (hybridization of native viruses, cross-reaction and selection of recombinants at temperatures of 25, 32 and 40 degrees C) to study their effects on the degree of attenuation and the regularity of transmission of the ts marker. The recombinants examined varied in thermosensitivity which depended on the conditions of recombination of parent viruses. All recombinants studied, irrespective of their RCT40 marker, were innocuous for men.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aleksandrova, G I" sort="Aleksandrova, G I" uniqKey="Aleksandrova G" first="G I" last="Aleksandrova">G I Aleksandrova</name><name sortKey="Garmashova, L M" sort="Garmashova, L M" uniqKey="Garmashova L" first="L M" last="Garmashova">L M Garmashova</name><name sortKey="Polezhaev, F I" sort="Polezhaev, F I" uniqKey="Polezhaev F" first="F I" last="Polezhaev">F I Polezhaev</name><name sortKey="Rumovsky, V I" sort="Rumovsky, V I" uniqKey="Rumovsky V" first="V I" last="Rumovsky">V I Rumovsky</name><name sortKey="Smorodintsev, A A" sort="Smorodintsev, A A" uniqKey="Smorodintsev A" first="A A" last="Smorodintsev">A A Smorodintsev</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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